Further, the PDT-induced release of several immuno-stimulatory molecules, called damage-associated molecular patterns (DAMPs), such as ATP, calreticulin high-mobility group Box 1 (HMGB1), heat shock proteins 70 and 90, and cytokines/chemokines promotes the potentiation of innate and adaptive immunity, constituting an important factor in the long-term development of anticancer immunity and effective tumor control. This evidence concerns the gene HMGB1 and neoplasm.