The results showed that among all the prostate cancer cells, only PC3 prostate cancer cells that were more resistant and malignant than other types of cells responded to the bystander effect mediated by conditioned media from cells treated with low-level PDT, resulting in an increase in iNOS and S-nitrosoglutathione reductase in PC3 bystander cells. This evidence concerns the gene ADH5 and prostate cancer.