BAX and neuroblastoma: CNP-Cur and Dex-CNP-Cur formulations cause neuroblastomas to produce more ROS and a significantly lower ratio of Bcl-2/Bax (Bax is an apoptosis-inducing gene and Bcl-2 stands for anti-apoptic factors), which leads to the release of cytochrome C and the activation of caspase 3/7 and apoptosis [134].