Levels of SOD, glutathione peroxidase (GPx) and glutathione reductase (GR) were lower in the serum of wet AMD patients of the age group 55–82 years compared with age-matched healthy control subjects [128], and SOD, catalase and GPx activities were also lower in erythrocytes of AMD patients vs. controls [129], indicating a strong correlation between wet AMD and oxidative stress and potentially dampened antioxidant enzyme functions in AMD. This evidence concerns the gene SOD1 and age-related macular degeneration.