NFE2L2 and malignant colon neoplasm: Additionally, CD133, a cancer stem cell marker of colon cancer, mediates a signaling pathway through the activation of 3-kinease/serine-threonine kinase (PI3K/AKT), resulting in an increase in Nrf2 protein levels and increasing sphere-formation capacity and proliferation, thus highlighting the significant role of the Nrf2 pathway in sustaining CSC-like properties [137].