After receiving IFN-I therapy, the primary establishment and multiplication of L. amazonensis infection is partially related to the enzyme superoxide dismutase 1 (SOD1), which is located downstream of Nrf2 and decreases the oxidative stress that is adverse to Leishmania and could boost the proliferation and affect the results of leishmaniasis [178,179]. The gene discussed is SOD1; the disease is leishmaniasis.