NFE2L2 and chronic obstructive pulmonary disease: In a different study, Harvey et al. investigated whether sulforaphane, a phytochemical, activated Nrf2 and restored alveolar macrophages’ ability to phagocytose nontypeable Haemophilus influenzae (NTHI) and Pseudomonas aeruginosa (PA) in patients with chronic obstructive pulmonary disease (COPD) [210].