POU5F1 and neoplasm: HPF treatment resulted in a decrease in OCT-4 expression, suggesting that the malignant characteristics of melanoma cells could be decreased by this treatment (Figure 4).Tyrosine-protein kinase receptor UFO (AXL) is a cell surface receptor with tyrosine-kinase activity that can enhance the signaling of growth factors, leading to epithelial-to-mesenchymal transition (EMT) and tumor dissemination [43].