ChN2 also exhibited a notable potency in the ischemia model (EC50 = 0.66 ± 0.23 μM), while QN23 (EC50 = 2.13 ± 0.47 μM) displayed a slightly higher EC50 value, although it was significantly lower than that of PBN (EC50 = 8.24 ± 1.49 μM) (Figure 4). Here, CHN2 is linked to ischemia.