RSV has been used for treatment in different AD animal models (APP/PS1 transgenic mice, Tg199589 transgenic mice, SAMP8 mice, Aβ-injected SD rats, and ovariectomized rats with chronic galactose injections) and for the treatment of healthy older adults, mild AD patients, or risk factors-associated AD people in clinical trials. The gene discussed is APP; the disease is Alzheimer disease.