In this study, PIC and its analogs GNT, RSV, RHA, and isoRHA were evaluated in vitro for their effects on Alzheimer’s disease-associated factors, including the DPPH radical scavenging activities, inhibitory activities against AChE, and Aβ peptide (1–42) aggregations and concentrations for 50% inhibitions (IC50) of each test compound; the inhibition modes were confirmed by molecular dockings. Here, ACHE is linked to Alzheimer disease.