In this regard, it is to be considered that (a) the α-Klotho protein may confer protection to the vascular endothelium due to its anti-inflammatory, antioxidant, and anti-apoptotic properties [186], and (b) uric acid has also been documented to stimulate tissue RAS and AngII production that mediates oxidative stress, inflammation, endothelial dysfunction, and vascular smooth muscle cell proliferation. Here, AGT is linked to endothelial dysfunction.