Although there have been studies on HMOX1 expression in the skin [28,29] and linking the over-expression of HMOX1 to dermatological disorders, such as psoriasis and atopic dermatitis, and to systemic diseases, such as systemic lupus erythematosus, no studies have yet investigated HMOX1 in DLE. Here, HMOX1 is linked to systemic lupus erythematosus.