Both molecules involved in cytoplasmic pre-microRNA processing, DICER1 (FC = −1.32, p ˂ 0.01) and TARBP2 (a gene that encodes TRBP; FC = 1.54, p ˂ 0.05), were found to be deregulated in ischemic origin heart failure observed in the patients (Figure 2C). Here, DICER1 is linked to heart failure.