In addition, studies have shown that the activities of superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px) in red blood cells and total antioxidant capacity in serum are reduced in patients with alopecia areata, supporting a possible role of oxidative stress in the pathogenesis of alopecia areata [7,8]. This evidence concerns the gene SOD1 and alopecia areata.