In response to PU-91, the heatmap demonstrated variability in the expression of BAX (e.g., AMD Patient #5, 1.6-fold increase and Patient #7, 0.7-fold decrease) and CASP3 (Patient #11, 1.6-fold increase and Patient #10, 0.7-fold decrease) (Figure 6b). Here, CASP3 is linked to age-related macular degeneration.