Figure 2b shows the heatmap representation for the responses of the individual cybrids within each group (NL, AMD, KC, and Glc). There was great variability in differential cellular metabolism response toward the PU-91, quercetin alone, or in combination (P+Q) within each disease group, representing the personalized responses due to each individual’s mitochondria influence. In the heatmap (Figure 2b), a percentage exceeding 100 indicates cells that are highly metabolically active, which represent higher viability. This evidence concerns the gene CALCA and age-related macular degeneration.