PPARGC1A and age-related macular degeneration: Our findings show that PGC-1α expression levels had a trend to increase in response to PU-91 treatment in all cybrid groups but achieved statistical significance only in AMD (5.4-fold, ±1.51, p-value = 0.015) and Glc cybrids (8-fold, ±0.56, p-value = 0.0014) (Figure 3a).