HAVCR2 and neoplasm: β2-adrenergic receptor blockade in mice exposed to chronic stress led to reductions in exhausted T cells and the expression of exhausted CD8+ T cell phenotypes (PD-1, LAG-3, TIM-3) on CD8+ TILs, enhanced metabolic activity and function of TILs, enhanced natural killer (NK) cells in the tumor microenvironment (TME), and suppressed tumor growth [47].