Interestingly, each of these dimensions can influence functionally important myeloid cells in the tumor microenvironment, e.g., β-catenin and decreased Batf3 DCs, gut microbiota and the shift from an M1 to M2 myeloid-derived suppressor cell phenotype, and germline PKCδ deficiency resulting in a shift to M1. The gene discussed is BATF3; the disease is neoplasm.