In summary, based on the human sample data, cell experiment and animal experiment, it was concluded that we identified a new functional circRNA, termed hsa_circ_0002348, demonstrating an evidence that it could regulate trophoblast proliferation and apoptosis mediated via hsa_circ_0002348/miR-126-3p/BAK1 axis in preeclampsia. Here, BAK1 is linked to preeclampsia.