On another hand, being a pro-inflammatory cytokine, produced in an early response to TNF-α [68], IL-6 will lead to iron sequestration in the presence of inflammation or iron overload [67] by stimulating hepcidin to degrade ferroprotein, thereby reducing bone marrow supply of iron and thus decreasing serum iron concentration [69] leading to anaemia. This evidence concerns the gene TNF and Tangier disease.