Two prediction models included in ROC analysis: model 1 with baseline characteristics only (including age, gender, smoking, alcohol consumption, hypertension, diabetes, and the levels of TC, TG, HDL-C, and LDL-C) as the reference model and model 2 with both baseline characteristics and all ABCG1 CpG cites. The gene discussed is ABCG1; the disease is diabetes mellitus.