Insulin resistance was casused by Serine phosphorylation of IRS substrates by jun N-terminal kinase (JNK1), and inhibitor of NF-κB-kinase β (IKKβ, an NF-κB-activating kinase) [21] Decreased insulin secretion and insulin resistance leads to hyperglycemia. The gene discussed is TBK1; the disease is Hyperglycemia.