Interestingly, a significant decrease in the vimentin and Slug (plasticity-associated factors) and the down-regulation of the activation and nuclear translocation of NF-κB (abolishing NF-κB driven gene expression of MMP9 and caspase-3) correlated to the ability of resveratrol to attenuate drug resistance in the 5-FU-resistant CRC cells [79]. The gene discussed is CASP3; the disease is colorectal carcinoma.