ALDH1A1 and colorectal carcinoma: In accordance therewith, Buhrmann et al. reported that resveratrol treatment chemosensitized HCT-116 CRC cells to 5-FU and induced apoptosis while suppressing NF-κB activation, EMT-plasticity (decreased slug and vimentin, increased E-cadherin) and CSC formation (decreased CD133, CD44, and ALDH1) via the modulation of the TNF-β signaling pathway [80].