One of the most essential and primary mechanisms of action of resveratrol is its anti-inflammatory potential, the suppression of the p38-MAPK signaling pathway, which is involved in the production of inflammatory mediators such as cytokines, COX-2, p53, and iNOS [243] and thus is an important requirement for the prevention and inhibition of colitis and CRC (Table 2). This evidence concerns the gene TP53 and colorectal carcinoma.