TNF and neoplasm: Moreover, these tumor-specific cytotoxic cells (CD8+ T-cells) can attack cancer cells through apoptosis-specific factors (IFN-γ, IL-4, and TNF-α) and mechanisms (perforation of the membrane) and initiate active suicide of tumor cells [239], promoted by resveratrol by participating in anti-tumor immunity, as reported by Choi and colleagues [240].