At 1:80 cut-off, the following antigenic specificities were identified: in MDS patients (n = 50/81), ANA profile was positive in 38% of cases (19/50 pts), dsDNA and ENA screen in 8% of cases (4/50 pts), Supplementary Fig. 2; In NHP patients’ group (n = 16/53), the association rates of antigenic specificity were 18.7% (3/16 pts) for ANA profile and 6.2% (1/16 pts) for ENA screen, whilst no positivity was found with dsDNA assay, Supplementary Fig. 3; finally, in the HD group (n = 5) no antigenic positivity was found, Supplementary Fig. 4. The gene discussed is BTG3; the disease is Huntington disease.