The reduction of ANA positive MDS patients at the clinically relevant cut-off of ≥ 1:160 suggest that the presence of anti-nuclear antibodies may be due not to a distinct autoimmune condition but rather to a general state of inflammation and immunological disorders, which could induce the production of different types of autoantibodies unable to recognize self-antigens. This evidence concerns the gene BTG3 and myelodysplastic syndrome.