The correlation analysis between patient age and ANA positivity showed an increasing trend in ANA positivity with increasing patients’ age, Supplementary Fig. 6A: in particular, results showed 10% (2/20 pts) of ANA ≥ 1:160 positive MDS in the group aged up to 65 years compared to MDS patients older than 65 years (27.9% 17/61 pts, p = 0.1339). The gene discussed is BTG3; the disease is myelodysplastic syndrome.