We hypothesized that an altered expression of proteins involved in the attraction of suppressive myeloid populations such as tumor-associated neutrophils (TANs) and tumor-associated macrophages (TAM)—like interleukin (IL)-1β or Hypoxia-inducible factor (HIF)-1α—may impact prognosis in these patients14,15. The gene discussed is HIF1A; the disease is neoplasm.