CXCL8 and neoplasm: This study in a large and homogenously treated iCCA cohort reveals a potential prognostic value of the IL-1B +3954 and the IL-8 -251 polymorphism for OS after curative-intent surgery for iCCA, consistent with our hypothesis that genetic variants of tumor-mediated immune suppression and angiogenesis may have additional clinical value for prognostic patient stratification.