Contrarily, other studies indicated that high ANXA1 expression is positively correlated with disease severity, increasing tumor stage72, and enhancing migration, through constitutive initiation of NF-κB73, and its downstream extracellular signal-regulated kinases (ERK) activation74, in addition to transforming growth factor beta (TGF-β)-dependent signaling promotion75. The gene discussed is ANXA1; the disease is neoplasm.