SPOCK2 and bronchopulmonary dysplasia: SPOCK2, a BPD susceptibility gene identified from GWAS7,30,31, was reported to be deleterious in BPD development as its overexpression in the lung altered neonatal mouse lung alveolarization and exacerbated hyperoxia-caused alveolar simplification while anti-SPOCK2 antibody treatment in mice improved it7,30.