In addition, BPD-CpG annotated genes observed on day 28 (Fig. 5B) were involved in immune and inflammatory events, including activation of immune and inflammatory cells, phagosome formation, infection, and platelet development (e.g., FCGR2A, GPR55, IGKV1-37, NFIB, TNFSF8), nucleotide metabolism (e.g., ADARB2, NME6), cholesterol metabolism (e.g., CYP27A1, MBTBS1), and oxidative stress (e.g., ALOX12, MAFF, NXN). The gene discussed is TNFSF8; the disease is bronchopulmonary dysplasia.