PIK3R3 and nervous system disorder: Enriched pathways of DEGs on day 28 were similar to those on day 14 such as chromosome segregation and DNA damage (e.g., BLM, CHEK1), activation of phagocytosis and degranulation (e.g., GNLY, MPO, LTF), leukocyte activation and immune response (e.g., IL23A, PIK3R3, RAG1, TRDC), neurological disorder (e.g., ATP6V1A, DUSP), and lipid metabolism (e.g., ACACA, SCD) (Fig. 5B; Additional file 1: Table S9).