LRRC10 knockout (Lrrc10–/–) mice exhibit mild systolic dysfunction, first detected at embryonic day (E)17.5 without changes in cardiac structure or evidence of fibrosis, and postnatally, the Lrrc10–/– mice gradually develop a dilated cardiomyopathy but exhibit normal survival11. The gene discussed is LRRC10; the disease is dilated cardiomyopathy.