In contrast, the substitution of BANAL-20-236 NTD with BANAL-20-52 NTD in BANAL-20-236 S protein decreased the infection on 293/hACE2 cells by 3-fold (Fig. 1i), while increased the transduction on CaLu3 cells by more than 2.7-fold (Fig. 1j). The gene discussed is PROS1; the disease is infection.