TNF and Hepatic fibrosis: In our study, we demonstrated that exposing umbilical cord-MSCs (UC-MSCs) to liver fibrosis-related factors, including Transforming Growth Factor beta (TGFβ), Tumor Necrosis Factor alpha (TNFα) and Interferon gamma (IFNγ), which could partially mimic the liver fibrotic microenvironment, resulted in cellular senescence and thus promoted hepatic stellate cells (HSCs) activation.