Of particular relevance to this study, we found that axon guidance, one of the several endogenous mechanisms for recovery after brain ischemia [16], was among the pathways overrepresented in the Reactome pathways, with the appearance of proteins like IQGAP2, Trio, Teneurin-4, Semaphorin 6A, Serpine2, Spondin-1, Ephrin type receptor 5. This evidence concerns the gene SERPINE2 and brain ischemia.