The above increase in discrimination between healthy and tumor cells with increasing KD upto a certain limit is qualitatively consistent with experiments (Caruso et al, 2015) with CAR T cells interacting with target cells expressing low (∼30,899 molecules/cell [Caruso et al, 2015]) and high (∼628,265 molecules/cell [Caruso et al, 2015]) EGFR abundances where the CAR was generated from high-affinity cetuximab (KD = 1.9 nM [Talavera et al, 2009]) or low-affinity nimotuzumab (KD = 21 nM [Talavera et al, 2009]). Here, EGFR is linked to neoplasm.