ALDH1L2 and colorectal carcinoma: ALDH1L2 knockdown inhibited the proliferation of HCT116 cells, which can be rescued by reexpression of ALDH1L2 WT, but not K70Q mutant (Fig. 5B), indicating that K70 acetylation reduces the activity of ALDH1L2 and impairs its ability to sustain CRC cell proliferation.