EGFR and cancer: In fact, recurring charge-changing mutations (e.g., Arg to His) have been documented in the epidermal growth factor receptor, the tumor suppressor protein p53, Ras-GRP1, and β-catenin, which alters their activities in cancer cells bearing an alkaline pHi and contributes to the transformed behaviors of the cells bearing these mutations (44, 80, 81, 82).