In summary, our above findings suggested that NOP14 could induce activation of E2F4 by upregulating its expression or miR17-5p/P130 signaling to facilitate transcription of multiple targeted genes, including CCND1, CCNE1, PIM1, E2F1, AKT1 and PVT1 etc., which ultimately promoted tumor cell proliferation in pancreatic cancer (Figure 5B). Here, CCNE1 is linked to familial pancreatic carcinoma.