E2F4 and familial pancreatic carcinoma: In summary, our above findings suggested that NOP14 could induce activation of E2F4 by upregulating its expression or miR17-5p/P130 signaling to facilitate transcription of multiple targeted genes, including CCND1, CCNE1, PIM1, E2F1, AKT1 and PVT1 etc., which ultimately promoted tumor cell proliferation in pancreatic cancer (Figure 5B).