To better understand the correlation between gene expression and the prognosis of AML, we performed survival analysis using the TCGA LAML dataset and found patients with higher expressions of PARP10 correlated with inferior OS and EFS compared to patients with lower expressions of PARP10, whereas PARP6 expression had no influence on the AML prognosis. The gene discussed is PARP6; the disease is acute myeloid leukemia.