MTOR and acute myeloid leukemia: KEGG pathway analysis revealed that the 558 positively co-expressed genes were significantly enriched in the oncogenic pathways (e.g., MAPK signaling pathway, AMPK signaling pathway, NF-kappa B signaling pathway, mTOR signaling pathway, and pancreatic cancer), and intriguingly, the chronic myeloid leukemia and acute myeloid leukemia pathways were also among the top enriched pathways (adjusted P < 0.05), indicating that PARP10 is highly relevant to AML, potentially through these functional pathways (Figure 5A and Supplementary Table 2).