Next, we conducted a validation analysis of the GEO database (GSE15061) and found that PARP3, PARP6, PARP10, and PARP11 genes exhibited a similar differential expression pattern, whereby these genes showed significantly higher expressions in AML patients compared to normal bone marrow cells, in both databases (Figure 1 and Supplementary Figure 2). The gene discussed is PARP3; the disease is acute myeloid leukemia.