Of note, the expression level of GPR30 was observed to be abnormally low in patients with inflammatory bowel disease, and GPR30‐specific inhibitor G15 impaired the protective effects of dehydroepiandrosterone on the intestinal barrier and inflammatory response in mice with colitis, reflecting that GPR30 played a key role in intestinal injury.10, 11. This evidence concerns the gene GPER1 and inflammatory bowel disease.