Unlike the downregulation of Triad3A and TRAF3 in LPS‐treated macrophages, studies have shown that Triad3A negatively regulates TRAF3 through Lys48‐linked ubiquitination, knock‐down of Triad3A increased endogenous TRAF3 expression in A549 cells following virus infection.41 Here, TRAF3 is linked to viral infectious disease.