The mRNA expression of TP53 (FC = 0.65, p = .000), BAX (FC = 0.76, p = .008), FOXO1 (FC = 0.59, p = .000), and RB1(FC = 0.50, p = .000) were significantly reduced in PBMCs of RA patients in comparison to controls (Figure 1). This evidence concerns the gene FOXO1 and rheumatoid arthritis.