To further explore the biological function of KLF5 and MX1 in the progression of renal fibrosis, we transfected si‐KLF5 or cotransfected si‐KLF5 and oe‐MX1 into HK‐2 cells, followed by 24‐h stimulation with TGF‐β1. The gene discussed is KLF5; the disease is renal fibrosis.