TNF and psoriasis: It is known that multiple danger signals can promote caspase‐1‐dependent production of inflammatory factors such as IL‐1β and IL‐18 via the NLRP3 inflammasome, which further cause immune cell activation such as T cells and natural killer cells, and release of inflammatory factors such as IFN‐γ and TNF‐α, which play important roles in the development of psoriasis.15