As shown in Fig 4 and S1 Raw images, treating MDA-MB-231, MCF-7 and H292 cells lines with 20μM AdOx for 72h reduced the expression of ATG7 and the ratio of LC3-II to LC3-I, and increased the expression of p62, showing that AdOx inhibited the autophagy of the three cancer cell lines. Here, SQSTM1 is linked to cancer.