The 17q21.31-inv or its local genes have been associated with neurodegenerative disorders.24,25,72 8p23.1-inv was associated with increased risk of autism and neuroticism.20,73,74 The MSRA gene located at 8p23.1 has been linked to bipolar disorder, schizophrenia, autism, and alcohol use disorder.75 CNVs at 16p11.2 showed strong association with autism.76,77 The 6p21.33-inv is located within the major histocompatibility complex, which has been linked to schizophrenia (e.g., C4A) and mood disorders.75,78. This evidence concerns the gene MSRA and alcohol abuse.