PRAMEF14 and hepatocellular carcinoma: In HCC HepG2 cells PRAMEF 14, SLAMF 9, TTC-36, LECT2, and PDLIM4 genes were upregulated after MC-LR treatment, whereas CYN exposure downregulated PRAMEF14, GPR52, CAPZA3, LECT2, CGS, TPRM1, TEK, PDLIM2, and TFF1 in HepG2 cells (Figure 8C, left and right panels).