In zebrafish (KrasV12 transgenic a doxycycline-inducible HCC model) MC-LR (3 μg/L) increased HCC progression by downregulation of serine/threonine phosphatase 2A (PP2A) and by upregulation of β-Catenin in the Wnt signaling pathway [25]. This evidence concerns the gene PTPA and hepatocellular carcinoma.