Moreover, functional autophagy (lipophagy) clears the accumulation of lipid droplets and reduces lipotoxicity in the liver by enhancing lipid metabolism [56,63,64], and our data suggest that cyanotoxins activate AKT/mTOR signaling partially, suppress autophagy by increasing the expression of p62, and increase cell steatosis in HCC cells. This evidence concerns the gene AKT1 and hepatocellular carcinoma.