Interestingly, exposure to MC-LR increased ACC, FASN, and SCD1 proteins in SK-Hep1 cells (although not significantly); however, compared with vehicle-treated HepG2 cells, ACC protein expression was increased in HepG2 cells and increased expression of SCD1 and SREBP1 was also observed slightly when cells were exposed to MC-LR for 30 days (Figure 6B, left and right panels) suggesting that chronic exposure to MC-LR regulates lipogenesis in HCC cells. The gene discussed is SREBF1; the disease is hepatocellular carcinoma.