INS and type 1 diabetes mellitus: Despite the advances in technology and insulin delivery over the past several decades, less than a third of adults with type 1 diabetes in England and Wales achieve a target HbA1c of ≤58 mmol/mol [7.5%] [8], and only 20% of patients in the US T1D Exchange Registry achieved HbA1c ≤53 mmol/mol [7.0%] [9].