VEGFA and atherosclerosis: Its main components play a role in the prevention and treatment of IS by reducing the level of EAA neurotransmitter Glu,[48] promoting endothelial cells to release neurotrophic factors VEGF-A and BDNF,[49] enhancing nerve cell to resistance damage,[50] promoting the proliferation of neural stem cells and regulating cholesterol levels.[51,52] This role is mainly related to lipids, ion channels, atherosclerosis pathways and neurodegeneration pathways.