WDFY3 and epilepsy: Wegiel et al have shown that chromosome 15q11.2-13.1 duplication syndrome has more serious focal developmental defects, which may lead to early onset of refractory epilepsy and sudden death from epilepsy.[43] Orosco et al found that deletion of the Wdfy3 gene resulted in migration defects in cortical projection neurons, leading to a significant co-disease of epilepsy and autism.[44]