MGMT and central nervous system cancer: Isocitrate dehydrogenase 1 (IDH 1) and O6-methylguanine-DNA methyltransferase (MGMT) were the most commonly used molecular biomarkers, and their diagnostic or prognostic value of them in glioma had been widely reported.[4] The cost and complexity of the test technology have limited their widespread application, and these molecular markers can only be obtained via postoperative testing.