A final example is the study of Chang et al., who described the cytotoxic effect of hepcidin, a peptide obtained from tilapia fish (Oreochromis mossambicus) with the capacity to induce necrosis at concentrations above 100 μM, and apoptosis at lower concentrations (50 μM), in hepatocellular carcinoma and fibrosarcoma cells [62]. This evidence concerns the gene HAMP and hepatocellular carcinoma.