AKR1B1 and type 2 diabetes mellitus: The purpose of this work is a comprehensive study of the effect of TNIC-ThS on the therapeutic targets of T2DM in vitro: the ability to bind lipid membranes, inhibit lipid peroxidation (LPO) and non-enzymatic glycation of bovine serum albumin (BSA), as well as aldose reductase, of the enzyme that catalyzes the reduction in glucose to sorbitol in the polyol pathway.