So far, various regulators involved in autolysosome (ALP) pathways to promote α-syn degradation by activating autophagy, such as 5′AMP-activated protein kinase (AMP), mammalian target of rapamycin 1 (mTORC1), UNC-51-like kinase 1 (ULK1), IMPase, LRRK2, beclin-1, transcription factor EB (TFEb), GCase, estrogen-related receptor (ERRα), and c-Abelson (c-ABL) have been proven to be targets and their activators or inhibitors have provided promising use in PD treatment [91]. The gene discussed is TFEB; the disease is Parkinson disease.