These cytokine improvements can either be through the reduction of inflammatory cytokines, such as reductions in CRP, TNF-α and IL-6 in psoriasis patients after treatment with Bifidobacterium infantis [16], or through the upregulation of anti-inflammatory cytokines, such as increases in IL-10 shown in animal models in conjunction with skin improvements after probiotic treatment [17]. This evidence concerns the gene CRP and psoriasis.