NET1 and hepatocellular carcinoma: They compared different delivery mechanisms, including biotin–avidin-created NBs conjugated with a NET-1 siRNA complex (Figure 7, Group E), which ultimately showed the most significant decrease in tumor growth within mice that were subcutaneously injected with HCC tumor cells, with all groups being irradiated with low-frequency US of 1 MHz of 1 W/cm2 (Figure 7).