The mean CD4+ cell count was lower in patients diagnosed with onychomycosis compared to those without onychomycosis (0.38 ± 0.30 vs. 0.49 ± 0.32, p = 0.03), and the prevalence of onychomycosis increased in advanced stages of HIV disease (21% stage A disease, 30% stage B, 54% stage C, p < 0.02) [17]. This evidence concerns the gene CD4 and tinea unguium.