Upon multivariable analyses (adjusted for age, gender, BMI, diabetes, CAD, HF, AF, dyslipidaemia, statins, E/E’, LVEF, triglycerides, eGFR, and CRP), the significant predictors of lower plasma SFRP5 levels were CAD (β = −0.36, p = 0.019), HF (β = −0.64, p = <0.001), statin use (β = −0.24, p = 0.050), CRP (β = −0.12, p = 0.010), and eGFR (β = −0.01, p = 0.014) (Table 4), while LVEF (β = 0.12, p = 0.016) and triglyceride levels (β = 0.24, p = 0.042) were associated with higher SFRP5 levels, as shown in Table 4. The gene discussed is CRP; the disease is atrial fibrillation.